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Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1

23 Oct 2023

Abstract excerpt

The endoplasmic reticulum (ER) forms contacts with the lysosomal compartment, regulating lysosome positioning and motility. The movements of lysosomes are controlled by the attachment of molecular motors to their surface. However, the molecular mechanisms by which ER controls lysosome dynamics are still elusive. Here, using mouse brain extracts and mouse embryonic fibroblasts, we demonstrate that spatacsin is an...

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PMID: 37871017
DOI: 10.1371/journal.pbio.3002337

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