Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.

Journal of cell science - 1 Nov 2014

Li Ke, Yang Lin, Zhang Cheng, Niu Yang, Li Wei, Liu Jia-Jia

Abstract excerpt

Hermansky-Pudlak syndrome 6 protein (HPS6) has originally been identified as a subunit of the BLOC-2 protein complex that is involved in the biogenesis of lysosome-related organelles. Here, we demonstrate that HPS6 directly interacts with the dynactin p150(Glued) subunit of the dynein-dynactin motor complex and acts as cargo adaptor for the retrograde motor to mediate the transport of lysosomes from the cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dynactin Complex
Share to HeLa Cells
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Lysosomes

Share to Microscopy, Confocal

Share to Microtubule-Associated Proteins

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 25189619
DOI: 10.1242/jcs.141978

Genes

HPS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.PMID 25189619Read ↗

Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles.Semantic proximity Read ↗

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1Semantic proximity Read ↗

Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4.Semantic proximity Read ↗

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.Semantic proximity Read ↗

The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseasesSemantic proximity Read ↗

Pathogenic variants in<i>BORCS5</i>Cause a Spectrum of Neurodevelopmental and Neurodegenerative Disorders with Lysosomal DysfunctionSemantic proximity Read ↗

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.Semantic proximity Read ↗

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Semantic proximity Read ↗

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.Semantic proximity Read ↗

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.Semantic proximity Read ↗

Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5.Semantic proximity Read ↗

A Mutation in the Borcs7 Subunit of the Lysosome Regulatory BORC Complex Results in Motor Deficits and Dystrophic Axonopathy in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.