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CHEK2 signaling is the key regulator of oocyte survival after chemotherapy

20 Oct 2023

Abstract excerpt

Cancer treatments can damage the ovarian follicle reserve, leading to primary ovarian insufficiency and infertility among survivors. Checkpoint kinase 2 (CHEK2) deficiency prevents elimination of oocytes in primordial follicles in female mice exposed to radiation and preserves their ovarian function and fertility. Here, we demonstrate that CHEK2 also coordinates the elimination of oocytes after exposure to...

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PMID: 37862420
DOI: 10.1126/sciadv.adg0898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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