Article

CHEK2 SIGNALING IS THE KEY REGULATOR OF OOCYTE SURVIVAL AFTER CHEMOTHERAPY

2021-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Radiation and chemotherapy can damage the primordial follicle reserve in female cancer patients leading to ovarian failure and infertility. Preservation of ovarian function requires treatment strategies that prevent loss of immature oocytes in primordial follicles during cancer therapy. Checkpoint kinase 2 (CHEK2) inhibition prevents loss of primordial oocytes caused by DNA damage and thus is a...

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Literature Corpus work: c7e114b4-8f6e-5b8b-b827-718775b075f4
DOI: 10.1101/2021.09.23.461589

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