Article

Inhibition of oogenic JNK preserves fertility and ovarian hormones during DNA-damaging cancer therapy

2026-05-01

Abstract excerpt

Primary ovarian insufficiency (POI) and related infertility, early menopause, and endocrine disorders due to hormonal deficiency are major side effects in young female cancer patients undergoing cancer therapy. Current strategies preserving the fertility and hormonal functions of the ovary remain imperfect due to concerns of feasibility, efficacy, or safety. Herein, we identified c-Jun N-terminal kinase (JNK) as a...

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Literature Corpus work: 18ff71fd-6925-518f-a93f-cd4916ff87a2
DOI: 10.64898/2026.04.28.721450

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