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DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve

19 Nov 2022

Abstract excerpt

Chemotherapy regimens and radiotherapy are common strategies to fight cancer. In women, these therapies may cause side effects such as premature ovarian insufficiency (POI) and infertility. Clinical strategies to protect the ovarian reserve from the lethal effect of cancer therapies needs better understanding of the mechanisms underlying iatrogenic loss of follicle reserve. Recent reports demonstrate a critical...

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PMID: 36430860
DOI: 10.3390/ijms232214379

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