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The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in Staphylococcus aureus

16 Oct 2023

Abstract excerpt

ABSTRACT Among the 16 two-component systems in the opportunistic human pathogen Staphylococcus aureus , only WalKR is essential. Like the orthologous systems in other Bacillota, S. aureus WalKR controls autolysins involved in peptidoglycan remodeling and is therefore intimately involved in cell division. However, despite the importance of WalKR in S. aureus , the basis for its essentiality is not understood and...

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PMID: 37850732
DOI: 10.1128/mbio.02262-23

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