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SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus

15 Mar 2018

Abstract excerpt

The success of Staphylococcus aureus, as both a human and animal pathogen, stems from its ability to rapidly adapt to a wide spectrum of environmental conditions. Two-component systems (TCSs) play a crucial role in this process. Here, we describe a novel staphylococcal virulence factor, SpdC, an Abi-domain protein, involved in signal sensing and/or transduction. We have uncovered a functional link between the...

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PMID: 29543889
DOI: 10.1371/journal.ppat.1006917

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