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Article

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.

Nature communications - 18 Mar 2016

Ji Quanjiang, Chen Peter J, Qin Guangrong, Deng Xin, Hao Ziyang, Wawrzak Zdzislaw, Yeo Won-Sik, Quang Jenny Winjing, Cho Hoonsik, Luo Guan-Zheng, Weng Xiaocheng, You Qiancheng, Luan Chi-Hao, Yang Xiaojing, Bae Taeok, Yu Kunqian, Jiang Hualiang, He Chuan

Abstract excerpt

Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis. Despite the well-established intracellular regulatory mechanism, the role of this TCS in extracellular signal recognition and factors that modulate the activity of this TCS remain largely unknown. Here we identify the extracellular receptor of the kinase...

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Identifiers

PMID: 26987594
DOI: 10.1038/ncomms11000
PMCID: PMC4802049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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