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Article

Genetic basis of a spontaneous mutation's expressivity.

Genetics - 3 Mar 2022

Schell Rachel, Hale Joseph J, Mullis Martin N, Matsui Takeshi, Foree Ryan, Ehrenreich Ian M

Abstract excerpt

Genetic background often influences the phenotypic consequences of mutations, resulting in variable expressivity. How standing genetic variants collectively cause this phenomenon is not fully understood. Here, we comprehensively identify loci in a budding yeast cross that impact the growth of individuals carrying a spontaneous missense mutation in the nuclear-encoded mitochondrial ribosomal gene MRP20. Initial...

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Identifiers

PMID: 35078232
DOI: 10.1093/genetics/iyac013
PMCID: PMC8893249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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