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Article

Defining the Functional Influence of Endothelial Cell-Expressed Oncogenic Activating Mutations on Vascular Morphogenesis and Capillary Assembly.

The American journal of pathology - 1 Apr 2024

Lin Prisca K, Sun Zheying, Davis George E

Abstract excerpt

This study sought to define key molecules and signals controlling major steps in vascular morphogenesis, and how these signals regulate pericyte recruitment and pericyte-induced basement membrane deposition. The morphogenic impact of endothelial cell (EC) expression of activating mutants of Kirsten rat sarcoma virus (kRas), mitogen-activated protein kinase 1 (Mek1), phosphatidylinositol-4,5-bisphosphate 3-kinase...

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Identifiers

PMID: 37838010
DOI: 10.1016/j.ajpath.2023.08.017
PMCID: PMC10988768

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