Article
PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations.
Cell death & disease - 19 Jan 2018
di Blasio Laura, Puliafito Alberto, Gagliardi Paolo Armando, Comunanza Valentina, Somale Desiana, Chiaverina Giulia, Bussolino Federico, Primo Luca
Abstract excerpt
Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel-Trenaunay syndrome. Although VM are often limited to specific tissue areas and can be well treated, in extended or recurrent lesions novel therapeutic approaches are needed. We generated a...
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