Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence

30 May 2023

Abstract excerpt

BACKGROUND: Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by the cellular transcription machinery. This process is regulated by both viral and cellular factors, which are necessary for an efficient viral replication as well as for the setting up of viral latency, leading to a repressed transcription of the integrated provirus. RESULTS: In this study, we examined the role of two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA and Nucleic Acid Chemistry
Share to HIV/AIDS drug development and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37254203
DOI: 10.1186/s12977-023-00625-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequencePMID 37254203Read ↗

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription.Semantic proximity Read ↗

DNA Topoisomerase I differentially modulates R-loops across the human genomeSemantic proximity Read ↗

Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.Semantic proximity Read ↗

Papillomavirus E1 Protein Binds to and Stimulates Human Topoisomerase ISemantic proximity Read ↗

Roles of eukaryotic topoisomerases in transcription, replication and genomic stabilitySemantic proximity Read ↗

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infectionsSemantic proximity Read ↗

Type I DNA TopoisomerasesSemantic proximity Read ↗

Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We KnowSemantic proximity Read ↗

Topoisomerase I in Human Disease Pathogenesis and TreatmentsSemantic proximity Read ↗

Recent developments in DNA topoisomerase II structure and mechanismSemantic proximity Read ↗

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands.Semantic proximity Read ↗

Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.