Article
Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in mycobacteria.
Microbiology spectrum - 12 Dec 2023
Wang Shuai, Zhang Jingran, Hameed H M Adnan, Ding Jie, Guan Ping, Fang Xiange, Peng Jiacong, Su Biyi, Ma Shangming, Tan Yaoju, M Cook Gregory, Zhang Guoliang, Lin Yongping, Zhong Nanshan, Hu Jinxing, Liu Jianxiong, Zhang Tianyu
Abstract excerpt
IMPORTANCE: Fluoroquinolones (FQs) play a key role in the treatment regimens against tuberculosis and non-tuberculous mycobacterial infections. However, there are significant differences in the sensitivities of different mycobacteria to FQs. In this study, we proved that this is associated with the polymorphism at amino acid 17 of quinolone resistance-determining region of Gyrase A by gene editing. This is the...
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