Article
A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Nov 2021
Chauffour Aurélie, Morel Florence, Reibel Florence, Petrella Stéphanie, Mayer Claudine, Cambau Emmanuelle, Aubry Alexandra
Abstract excerpt
BACKGROUND: The fact that Mycobacterium leprae does not grow in vitro remains a challenge in the survey of its antimicrobial resistance (AMR). Mainly molecular methods are used to diagnose AMR in M. leprae to provide reliable data concerning mutations and their impact. Fluoroquinolones (FQs) are efficient for the treatment of leprosy and the main second-line drugs in case of multidrug resistance. OBJECTIVES: This...
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