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Molecular characterization of <i>Mycobacterium ulcerans</i> DNA gyrase and identification of mutations reduced susceptibility against quinolones <i>in vitro</i>

2021-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Buruli ulcer disease is a neglected necrotizing and disabling cutaneous tropical illness caused by Mycobacterium ulcerans ( Mul ). Fluoroquinolone (FQ), used in the treatment of this disease, has been known to act by inhibiting the enzymatic activities of DNA gyrase; however, the detailed molecular basis of these characteristics and the FQ resistance mechanisms in Mul remains unknown. This st...

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Literature Corpus work
8d3ee92d-337b-5b57-8858-3cf63bf8793a
DOI
10.1101/2021.09.29.462499
Open publication

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