Article
A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system.
The Journal of antimicrobial chemotherapy - 1 Apr 2012
Maruri Fernanda, Sterling Timothy R, Kaiga Anne W, Blackman Amondrea, van der Heijden Yuri F, Mayer Claudine, Cambau Emmanuelle, Aubry Alexandra
Abstract excerpt
Fluoroquinolone resistance in Mycobacterium tuberculosis has become increasingly important. A review of mutations in DNA gyrase, the fluoroquinolone target, is needed to improve the molecular detection of resistance. We performed a systematic review of studies reporting mutations in DNA gyrase genes in clinical M. tuberculosis isolates. From 42 studies that met inclusion criteria, 1220 fluoroquinolone-resistant...
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