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Article

Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium.

Microbiology spectrum - 15 Jun 2023

Thapa Jeewan, Chizimu Joseph Yamweka, Kitamura Soyoka, Akapelwa Mwangala Lonah, Suwanthada Pondpan, Miura Nami, Toyting Jirachaya, Nishimura Tomoyasu, Hasegawa Naoki, Nishiuchi Yukiko, Gordon Stephen V, Nakajima Chie, Suzuki Yasuhiko

Abstract excerpt

Mycobacterium avium, a member of the M. avium complex (MAC), is the major pathogen contributing to nontuberculous mycobacteria (NTM) infections worldwide. Fluoroquinolones (FQs) are recommended for the treatment of macrolide-resistant MACs. The association of FQ resistance and mutations in the quinolone resistance-determining region (QRDR) of gyrA of M. avium is not yet clearly understood, as many FQ-resistant...

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Identifiers

PMID: 37067420
DOI: 10.1128/spectrum.05088-22
PMCID: PMC10269562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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