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Interplay between Amino Acid Substitution in GyrA and QnrB19: Elevating Fluoroquinolone Resistance in Salmonella Typhimurium.

ACS infectious diseases - 9 Aug 2024

Suwanthada Pondpan, Kongsoi Siriporn, Jayaweera Sasini, Akapelwa Mwangala Lonah, Thapa Jeewan, Nakajima Chie, Suzuki Yasuhiko

Abstract excerpt

Globally, there have been increasing reports of antimicrobial resistance in nontyphoidal Salmonella (NTS), which can develop into severe and potentially life-threatening diarrhea. This study focuses on the synergistic effects of DNA gyrase mutations and plasmid-mediated quinolone resistance (PMQR) genes, specifically qnrB19, on fluoroquinolone (FQ) resistance in Salmonella Typhimurium. By utilizing recombinant...

Topics

DNA Gyrase
Salmonella typhimurium
Fluoroquinolones
Anti-Bacterial Agents
Microbial Sensitivity Tests
Drug Resistance, Bacterial
Amino Acid Substitution
Bacterial Proteins
Ciprofloxacin
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

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Identifiers

PMID: 38898378
DOI: 10.1021/acsinfecdis.4c00150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Interplay between Amino Acid Substitution in GyrA and QnrB19: Elevating Fluoroquinolone Resistance in Salmonella Typhimurium.PMID 38898378Read ↗

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