Effects of Mutating Trp42 Residue on γD-Crystallin Stability.

Abstract excerpt

Oligomerization and aggregation of γD-crystallins (HγDC) in the eye lens is one of the main causes of cataract development. To date, several congenital mutations related to this protein are known to promote the formation of aggregates. Previous studies have demonstrated that mutations in W42 residue of HγDC lead to the generation of partially unfolded intermediates that are more prone to aggregate. To understand...

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• gamma-Crystallins
• Hydrophobic and Hydrophilic Interactions
• Molecular Dynamics Simulation
• Protein Conformation
• Protein Stability