Genotyping, sequencing and analysis of 140,000 adults from Mexico City.

doi:10.1038/s41586-023-06595-3

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Genotyping, sequencing and analysis of 140,000 adults from Mexico City.

Nature - 1 Oct 2023

Ziyatdinov Andrey, Torres Jason, Alegre-Díaz Jesús, Backman Joshua, Mbatchou Joelle, Turner Michael, Gaynor Sheila M, Joseph Tyler, Zou Yuxin, Liu Daren, Wade Rachel, Staples Jeffrey, Panea Razvan, Popov Alex, Bai Xiaodong, Balasubramanian Suganthi, Habegger Lukas, Lanche Rouel, Lopez Alex, Maxwell Evan, Jones Marcus, García-Ortiz Humberto, Ramirez-Reyes Raul, Santacruz-Benítez Rogelio, Nag Abhishek, Smith Katherine R, Damask Amy, Lin Nan, Paulding Charles, Reppell Mark, Zöllner Sebastian, Jorgenson Eric, Salerno William, Petrovski Slavé, Overton John, Reid Jeffrey, Thornton Timothy A, Abecasis Gonçalo, Berumen Jaime, Orozco-Orozco Lorena, Collins Rory, Baras Aris, Hill Michael R, Emberson Jonathan R, Marchini Jonathan, Kuri-Morales Pablo, Tapia-Conyer Roberto

Abstract excerpt

The Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City1. Here we generated genotype and exome-sequencing data for all individuals and whole-genome sequencing data for 9,950 selected individuals. We describe high levels of relatedness and substantial heterogeneity in ancestry composition...

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PMID: 37821707
DOI: 10.1038/s41586-023-06595-3
PMCID: PMC10600010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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