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Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.

PloS one - 1 Jan 2021

Aguilar-Ordoñez Israel, Pérez-Villatoro Fernando, García-Ortiz Humberto, Barajas-Olmos Francisco, Ballesteros-Villascán Judith, González-Buenfil Ram, Fresno Cristobal, Garcíarrubio Alejandro, Fernández-López Juan Carlos, Tovar Hugo, Hernández-Lemus Enrique, Orozco Lorena, Soberón Xavier, Morett Enrique

Abstract excerpt

There has been limited study of Native American whole genome diversity to date, which impairs effective implementation of personalized medicine and a detailed description of its demographic history. Here we report high coverage whole genome sequencing of 76 unrelated individuals, from 27 indigenous groups across Mexico, with more than 97% average Native American ancestry. On average, each individual has 3.26...

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PMID: 33831079
DOI: 10.1371/journal.pone.0249773
PMCID: PMC8031408

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