Article
Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.
Science (New York, N.Y.) - 13 Jun 2014
Moreno-Estrada Andrés, Gignoux Christopher R, Fernández-López Juan Carlos, Zakharia Fouad, Sikora Martin, Contreras Alejandra V, Acuña-Alonzo Victor, Sandoval Karla, Eng Celeste, Romero-Hidalgo Sandra, Ortiz-Tello Patricia, Robles Victoria, Kenny Eimear E, Nuño-Arana Ismael, Barquera-Lozano Rodrigo, Macín-Pérez Gastón, Granados-Arriola Julio, Huntsman Scott, Galanter Joshua M, Via Marc, Ford Jean G, Chapela Rocío, Rodriguez-Cintron William, Rodríguez-Santana Jose R, Romieu Isabelle, Sienra-Monge Juan José, del Rio Navarro Blanca, London Stephanie J, Ruiz-Linares Andrés, Garcia-Herrera Rodrigo, Estrada Karol, Hidalgo-Miranda Alfredo, Jimenez-Sanchez Gerardo, Carnevale Alessandra, Soberón Xavier, Canizales-Quinteros Samuel, Rangel-Villalobos Héctor, Silva-Zolezzi Irma, Burchard Esteban Gonzalez, Bustamante Carlos D
Abstract excerpt
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some...
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