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Article

Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Aug 2016

Larsen Hege E, Bardsley Emma N, Lefkimmiatis Konstantinos, Paterson David J

Abstract excerpt

UNLABELLED: Hypertension is associated with impaired nitric oxide (NO)-cyclic nucleotide (CN)-coupled intracellular calcium (Ca(2+)) homeostasis that enhances cardiac sympathetic neurotransmission. Because neuronal membrane Ca(2+) currents are reduced by NO-activated S-nitrosylation, we tested whether CNs affect membrane channel conductance directly in neurons isolated from the stellate ganglia of spontaneously...

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Identifiers

PMID: 27535905
DOI: 10.1523/JNEUROSCI.1059-16.2016
PMCID: PMC4987433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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