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Article

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin.

Nature communications - 7 Oct 2023

Xiao Qian, Mears Joseph, Nathan Aparna, Ishigaki Kazuyoshi, Baglaenko Yuriy, Lim Noha, Cooney Laura A, Harris Kristina M, Anderson Mark S, Fox David A, Smilek Dawn E, Krueger James G, Raychaudhuri Soumya

Abstract excerpt

Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood. Using longitudinal skin biopsies (n = 375) from the "Psoriasis Treatment with Abatacept and Ustekinumab: A Study of Efficacy"(PAUSE) clinical trial (n = 101), we report 953 expression...

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Identifiers

PMID: 37805522
DOI: 10.1038/s41467-023-41984-2
PMCID: PMC10560299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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