Article
Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9.
Genome medicine - 6 Oct 2023
Guo Tao, Chen Guo-Qiao, Li Xu-Fan, Wang Meng, Liu Kun-Ming, Yang Xiao-Ying, Liu Si-Cheng, Feng Yi-Li, Liu Peng-Yuan, Lin Hui, Xie An-Yong
Abstract excerpt
BACKGROUND: Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer treatment. CRISPR/Cas9-induced mouse liver cancer models can be used to elucidate how IGH is developed. However, as CRISPR/Cas9 could induce chromothripsis and extrachromosomal DNA in cells in addition to targeted mutations, we wondered whether this effect...
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