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Article

Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice

21 Sept 2012

Abstract excerpt

OBJECTIVES: Previous studies have suggested an important role of the transcription factor Gata6 in endocrine pancreas, while GATA6 haploinsufficient inactivating mutations cause pancreatic agenesis in humans. We aimed to analyse the effects of Gata6 inactivation on pancreas development and function. DESIGN: We deleted Gata6 in all epithelial cells in the murine pancreas at the onset of its development. Acinar...

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PMID: 23002247
DOI: 10.1136/gutjnl-2012-303328

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