Article
Its all about IFN-λ4: Protective role of IFNL4 polymorphism against COVID-19-related pneumonia in females.
Journal of medical virology - 1 Oct 2023
Matic Sanja, Milovanovic Dragan, Mijailovic Zeljko, Djurdjevic Predrag, Sazdanovic Predrag, Stefanovic Srdjan, Todorovic Danijela, Popovic Suzana, Vitosevic Katarina, Vukicevic Vladimir, Vukic Milena, Vukovic Nenad, Milivojevic Nevena, Zivanovic Marko, Jakovljevic Vladimir, Filipovic Nenad, Djordjevic Natasa, Baskic Dejan
Abstract excerpt
Despite the pivotal role of IFN-λs in the innate immune response, the data on its genetic polymorphism in relation to COVID-19 severity are scarce and contradictory. In the present study, we aimed to determine if the presence of the most frequent functional single nucleotide polymorphisms (SNPs) of the two most important IFN-λs coding genes, namely IFNL3 and IFNL4, alters the likelihood of SARS-CoV-2-infected...
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