Article
Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese.
Arthritis research & therapy - 29 Aug 2018
Chen Ji-Yih, Wang Chin-Man, Chen Tai-Di, Jan Wu Yeong-Jian, Lin Jing-Chi, Lu Ling Ying, Wu Jianming
Abstract excerpt
BACKGROUND: Type III interferons (IFNs) or IFN-λs are the newly discovered cytokines that primarily target the cells of epithelial and myeloid lineages, which are major components of kidneys. The current study aimed to investigate whether IFN-λs are involved in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis. METHODS: TaqMan allele discrimination assays were used to determine IFNL3/4...
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