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Article

Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology-based approach.

NPJ systems biology and applications - 18 May 2020

Hari Kishore, Sabuwala Burhanuddin, Subramani Balaram Vishnu, La Porta Caterina A M, Zapperi Stefano, Font-Clos Francesc, Jolly Mohit Kumar

Abstract excerpt

Metastasis is the cause of over 90% of cancer-related deaths. Cancer cells undergoing metastasis can switch dynamically between different phenotypes, enabling them to adapt to harsh challenges, such as overcoming anoikis and evading immune response. This ability, known as phenotypic plasticity, is crucial for the survival of cancer cells during metastasis, as well as acquiring therapy resistance. Various...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32424264
DOI: 10.1038/s41540-020-0132-1
PMCID: PMC7235229

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