Article

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

2021-01-27

Abstract excerpt

“Stem-like” TCF1 + CD8 + T cells (T SL ) are necessary for long-term maintenance of T cell responses and the efficacy of immunotherapy but, as tumors contain signals that should drive T-cell terminal-differentiation, how these cells are maintained in tumors remains unclear. We found that a small number of TCF1 + tumor-specific CD8 + T cells were present in tumors throughout development. Yet, most intratumoral...

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Literature Corpus work: cfd3913d-8d03-5a5b-9028-648dc1ea191b
DOI: 10.1101/2021.01.27.428467

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