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Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike

1 May 2023

Abstract excerpt

The global spread of the SARS-CoV-2 virus has resulted in emergence of lineages which impact the effectiveness of immunotherapies and vaccines that are based on the early Wuhan isolate. All currently approved vaccines employ the spike protein S, as it is the target for neutralizing antibodies. Here we describe two SARS-CoV-2 isolates with unusually large deletions in the N-terminal domain (NTD) of the spike....

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PMID: 37126534
DOI: 10.1371/journal.ppat.1011308

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