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Article

Multidrug resistance phenotype and its relation to stem cell characteristics in chronic myeloid leukemia.

Gene - 20 Jan 2024

Lettnin Aline Portantiolo, Wagner Eduardo Felipe, Salgado Mariana Teixeira Santos Figueiredo, Cañedo Andrés Delgado, Rumjanek Vivian Mary, Trindade Gilma Santos, Votto Ana Paula de Souza

Abstract excerpt

The present work aimed to evaluate the expression profile of genes related to stem cells (SC) characteristics during the acquisition of the multidrug resistance (MDR) phenotype in the chronic myeloid leukemia (CML). For this, the K562 (non MDR) and FEPS (MDR) cell lines were used. K562 cells had resistance induced by exposure to daunorubicin (DNR), and induction was confirmed by flow cytometry with an increase in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37774806
DOI: 10.1016/j.gene.2023.147848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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