Article
OCT4 mutations in human erythroleukemic cells: implications for multiple drug resistance (MDR) phenotype.
Molecular and cellular biochemistry - 1 Feb 2015
Oliveira Bruno Rodrigues, Figueiredo Marcio Azevedo, Trindade Gilma Santos, Marins Luis Fernando
Abstract excerpt
The OCT4 transcription factor is a crucial stem cells marker and it has been related to the cancer stem cells concept. Moreover, it has also been associated to the multiple drug resistance (MDR) phenotype. Our first results pointed out a straight relation between OCT4 and ABC transporters in K562-derivative MDR (Lucena) cells. Sequencing of ABC promoters did not reveal any mutation that could explain the...
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