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TRAIL ‐conjugated liposomes that bind natural killer cells to induce colorectal cancer cell apoptosis

29 Sept 2023

Abstract excerpt

Natural killer (NK) cell functionality is a strong indicator of favorable prognosis in cancer patients, making NK cells an appealing therapeutic target to prevent lymph node dissemination. We engineered liposomes that are conjugated with anti-CD335 antibodies for NK cell targeting, and the apoptotic ligand TRAIL to kill cancer cells. Liposomes were made using a thin film hydration method followed by extrusion to...

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PMID: 37772330
DOI: 10.1002/jbm.a.37621

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