Article

Next generation protein-corrole bio-assemblies provide effective tumoricidal treatment in a metastatic triple-negative breast cancer model

2026-02-24

Abstract excerpt

<title>Abstract</title> <p>Assemblies that combine chemotherapeutics with tumor-targeting proteins are promising agents for treating resistant cancers but require full biochemical characterization before therapeutic deployment. We developed and optimized a HER3-targeting capsomere, HPK2.0, which forms stable nanoscale assemblies with cytotoxic corroles via electrostatic neutralization and shape complementarity. T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 43c8951e-245e-53d6-9937-e6b97422014f
DOI: 10.21203/rs.3.rs-8934510/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Next generation protein-corrole bio-assemblies provide effective tumoricidal treatment in a metastatic triple-negative breast cancer modelDOI 10.21203/rs.3.rs-8934510/v1Read

Next generation protein-corrole bio-assemblies provide effective tumoricidal treatment in a metastatic triple-negative breast cancer modelSemantic proximity Read

Red Blood Cell-derived Extracellular Vesicles enable Cisplatin and Cetuximab combined Therapy against Triple-Negative Breast CancerSemantic proximity Read

Effective Degradation of Wild-Type and Mutant EGFR Using Self-Assembling Peptide-Derived PROTAC Nanoparticles (NanoTACs) for Cancer Therapy.Semantic proximity Read

Redox-Responsive Theranostic Nanoplatforms in Oncology: Linking Tumor Microenvironment Biology, Proteasome Targeting, and Clinical TranslationSemantic proximity Read

Precision Nanotherapy for p53-Mutant Cancer Using Modular Triple-LNP DeliverySemantic proximity Read

A super-assembled synergistically nanoplatform AP@ZIF-8 Pt for hepatocarcinoma therapySemantic proximity Read

One Stone, Two Birds: A Peptide‐Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation TherapySemantic proximity Read

Modular supramolecular polycations enable efficient delivery of RNA therapeutics and vaccinesSemantic proximity Read

pH-Sensitive Shell–Core Platform Block DNA Repair Pathway To Amplify Irreversible DNA Damage of Triple Negative Breast CancerSemantic proximity Read

Local Delivery of Accutox® Synergises With Immune-checkpoint Inhibitors at Disrupting Tumor GrowthSemantic proximity Read

Extreme Hydrophobicity of Cytotoxic Drugs Enables Design of Next Generation Antibody-Drug Conjugates NanotherapeuticsSemantic proximity Read

From Small Molecules to Degraders and AI: Contemporary Trends and Future Directions in Anticancer Drug DiscoverySemantic proximity Read