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Effective targeting of CD19 positive primary B-ALL cells using CAR-NK cells generated with mRNA-LNPs

2024-11-21

Abstract excerpt

1. Chimeric antigen receptor natural killer (CAR-NK) cell therapy is recognized as a promising modality for the treatment of hematologic malignancies, particularly B-cell malignancies. In this study, we developed “off-the-shelf” anti-CD19 CAR-NK cells using anti-CD19 CAR mRNAs formulated in proprietary ionizable lipid nanoparticles (LNPs). The efficiency of mRNA-LNP delivery into umbilical cord blood (UCB)-derived...

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Identifiers and source

Literature Corpus work
ec43ed6c-e198-5fa6-af0d-8538cb68eb14
DOI
10.1101/2024.11.21.624707
Open publication

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Effective targeting of CD19 positive primary B-ALL cells using CAR-NK cells generated with mRNA-LNPsDOI 10.1101/2024.11.21.624707
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