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Article

Chemo-immunotherapy of colon cancer with focused ultrasound and Salmonella-laden temperature sensitive liposomes (thermobots).

Scientific reports - 30 Aug 2018

Ektate Kalyani, Munteanu Maria Cristina, Ashar Harshini, Malayer Jerry, Ranjan Ashish

Abstract excerpt

Using attenuated Salmonella that efficiently homes in solid tumors, here we developed thermobots that actively transported membrane attached low-temperature sensitive liposome (LTSL) inside colon cancer cells for triggered doxorubicin release and simultaneous polarized macrophages to M1 phenotype with high intensity focused ultrasound (HIFU) heating (40-42 °C). Biocompatibility studies showed that the synthesized...

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Identifiers

PMID: 30166607
DOI: 10.1038/s41598-018-30106-4
PMCID: PMC6117346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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