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Article

Unveiling the metal mutation nexus: Exploring the genomic impacts of heavy metal exposure in lung adenocarcinoma and colorectal cancer.

Journal of hazardous materials - 5 Jan 2024

Liu Mengyuan, Hong Yuting, Duan Xiaohong, Zhou Qiming, Chen Jing, Liu Siyao, Su Junyan, Han Li, Zhang Jiali, Niu Beifang

Abstract excerpt

Mutations that activate oncogenes and deactivate tumor suppressor genes are widely recognized as significant contributors to cancer development. We investigated relationships between heavy metal exposure and the frequencies and types of gene mutations in patients with lung adenocarcinoma (LUAD) and colorectal cancer (CRC). Plasma concentrations of arsenic (As), cadmium (Cd), chromium (Cr), mercury (Hg), and lead...

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Identifiers

PMID: 37769449
DOI: 10.1016/j.jhazmat.2023.132590

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