Article
Aluminum Concentration Is Associated with Tumor Mutational Burden and the Expression of Immune Response Biomarkers in Colorectal Cancers.
International journal of molecular sciences - 13 Dec 2024
Bonfiglio Rita, Giacobbi Erica, Palumbo Valeria, Casciardi Stefano, Sisto Renata, Servadei Francesca, Scioli Maria Paola, Schiaroli Stefania, Cornella Elena, Cervelli Giulio, Sica Giuseppe, Candi Eleonora, Melino Gerry, Mauriello Alessandro, Scimeca Manuel
Abstract excerpt
Environmental pollution poses a significant risk to public health, as demonstrated by the bioaccumulation of aluminum (Al) in colorectal cancer (CRC). This study aimed to investigate the potential mutagenic effect of Al bioaccumulation in CRC samples, linking it to the alteration of key mediators of cancer progression, including immune response biomarkers. Aluminum levels in 20 CRC biopsy samples were analyzed...
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