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Article

SPAG17 mediates nuclear translocation of protamines during spermiogenesis

12 Sept 2023

Abstract excerpt

Protamines (PRM1 and PRM2) are small, arginine-rich, nuclear proteins that replace histones in the final stages of spermiogenesis, ensuring chromatin compaction and nuclear remodeling. Defects in protamination lead to increased DNA fragmentation and reduced male fertility. Since efficient sperm production requires the translocation of protamines from the cytoplasm to the nucleus, we investigated whether SPAG17, a...

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PMID: 37766963
DOI: 10.3389/fcell.2023.1125096

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