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Fam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis

24 Jan 2025

Abstract excerpt

Chromatin remodeling, which involves the histone-to-protamine exchange process during spermiogenesis, is crucial for sperm nuclear condensation and male fertility. However, the key regulators and underlying molecular mechanisms involved in this process remain largely unexplored. In this study, we discovered that deficiency in the family with sequence similarity 170 member A (Fam170a) led to abnormal sperm nuclear...

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Share to Epigenetics and DNA Methylation
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PMID: 39868537
DOI: 10.1093/nar/gkaf023

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