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Article

Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2022

Harashima Shogo, Yamazaki Yuto, Motomura Naoki, Ono Yoshikiyo, Omata Kei, Tezuka Yuta, Morimoto Ryo, Nakamura Yasuhiro, Satoh Fumitoshi, Suzuki Hiroyoshi, Kwon Go Eun, Choi Man Ho, Sasano Hironobu

Abstract excerpt

Aldosterone-producing adenoma (APA) is histologically composed of clear and compact tumor cells. KCNJ5- mutated APAs were reported to be associated with higher plasma aldosterone concentration and more abundant clear tumor cells containing lipid droplets than non-KCNJ5- mutated APAs. However, the association among cholesterol uptake and/or synthesis, cellular morphology and genotypes has remained unknown....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35533918
DOI: 10.1016/j.jsbmb.2022.106116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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