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Article

TERTmonitor-qPCR Detection of TERTp Mutations in Glioma.

Genes - 25 Aug 2023

Brás João Paulo, Jesus Tito Teles, Prazeres Hugo, Lima Jorge, Soares Paula, Vinagre João

Abstract excerpt

Telomerase promoter (TERTp) mutations are frequently observed in various types of tumours and commonly characterised by two specific hotspots located at positions -124 and -146 upstream of the start codon. They enhance TERTp activity, resulting in increased TERT expression. In central nervous system (CNS) tumours, they are integrated as biomarkers, aiding in the diagnosis and with a role in prognosis, where, in...

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Identifiers

PMID: 37761833
DOI: 10.3390/genes14091693
PMCID: PMC10530400

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