Article
Regulation of human and mouse bystander T cell activation responses by PD-1.
JCI insight - 22 Sept 2023
Le Catherine T, Vick Logan V, Collins Craig, Dunai Cordelia, Sheng Michael K, Khuat Lam T, Barao Isabel, Judge Sean J, Aguilar Ethan G, Curti Brendan, Dave Maneesh, Longo Dan L, Blazar Bruce R, Canter Robert J, Monjazeb Arta M, Murphy William J
Abstract excerpt
Bystander activation of memory T cells occurs via cytokine signaling alone in the absence of T cell receptor (TCR) signaling and provides a means of amplifying T cell effector responses in an antigen-nonspecific manner. While the role of Programmed Cell Death Protein 1 (PD-1) on antigen-specific T cell responses is extensively characterized, its role in bystander T cell responses is less clear. We examined the...
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