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Article

Mechanism of dichotomy between CD8+ responses elicited by apoptotic and necrotic cells.

Cancer immunity - 1 Jan 2013

Buckwalter Matthew R, Srivastava Pramod K

Abstract excerpt

Apoptotic cells are significantly more immunogenic than necrotic cells, even though both forms are identical in antigenic content. When a combination of apoptotic and necrotic cells are used to immunize, the phenotype conferred by apoptotic cells, i.e., high immunogenicity, is dominant. However, necrotic cells are not immunosuppressive or tolerogenic. Apoptotic and necrotic cells are taken up by...

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Source

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Identifiers

PMID: 23390373
PMCID: PMC3559190

Genes

TLR4
TLR9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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