Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.

Immunology and cell biology - 1 Feb 2013

Jatzek Anna, Marie Tejera Melba, Plisch Erin H, Fero Matthew L, Suresh M

Abstract excerpt

CD8 T cells exhibit dynamic alterations in proliferation and apoptosis during various phases of the CD8 T-cell response, but the mechanisms that regulate cellular proliferation from the standpoint of CD8 T-cell memory are not well defined. The cyclin-dependent kinase inhibitor p27(Kip1) functions as a negative regulator of the cell cycle in T cells, and it has been implicated in regulating cellular processes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Dendritic Cells

Share to Gene Deletion

Share to Immunologic Memory

Share to Lymphocytic choriomeningitis virus

Source

Open in PubMed Open full text

Identifiers

PMID: 23207280
DOI: 10.1038/icb.2012.71
PMCID: PMC3570738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.PMID 23207280Read ↗

Memory-Phenotype CD4+ T Lymphocytes: A Double-Edged Sword in Immune Responses.Semantic proximity Read ↗

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral InfectionSemantic proximity Read ↗

Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4Semantic proximity Read ↗

Dissociating markers of senescence and protective ability in memory T cells.Semantic proximity Read ↗

Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner.Semantic proximity Read ↗

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytesSemantic proximity Read ↗

CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory CapacitySemantic proximity Read ↗

Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.Semantic proximity Read ↗

B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation.Semantic proximity Read ↗

HIV-1-Specific Memory CD4+ T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4+ T CellsSemantic proximity Read ↗

PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.Semantic proximity Read ↗

CD27-CD70 Costimulation Controls T Cell Immunity during Acute and Persistent Cytomegalovirus InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.