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Article

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy.

Journal for immunotherapy of cancer - 1 Jan 2017

Sckisel Gail D, Mirsoian Annie, Minnar Christine M, Crittenden Marka, Curti Brendan, Chen Jane Q, Blazar Bruce R, Borowsky Alexander D, Monjazeb Arta M, Murphy William J

Abstract excerpt

BACKGROUND: Studies assessing immune parameters typically utilize human PBMCs or murine splenocytes to generate data that is interpreted as representative of immune status. Using splenocytes, we have shown memory CD4-T cells that expand following systemic immunostimulatory therapies undergo rapid IFNg-mediated activation induced cell death (AICD) resulting in a net loss of total CD4-T cells which correlates with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28428882
DOI: 10.1186/s40425-017-0235-4
PMCID: PMC5394626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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