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Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance

20 Sept 2023

Abstract excerpt

Abstract Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). Here, we use single-cell RNA and T cell receptor sequencing to characterize bone marrow T cells from healthy adults ( n = 4) and patients with precursor...

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PMID: 37730678
DOI: 10.1038/s41467-023-41562-6

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