Article
Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma.
Cancer immunology research - 2 Nov 2022
Welters Carlotta, Lammoglia Cobo María Fernanda, Stein Christian Alexander, Hsu Meng-Tung, Ben Hamza Amin, Penter Livius, Chen Xiaojing, Buccitelli Christopher, Popp Oliver, Mertins Philipp, Dietze Kerstin, Bullinger Lars, Moosmann Andreas, Blanc Eric, Beule Dieter, Gerbitz Armin, Strobel Julian, Hackstein Holger, Rahn Hans-Peter, Dornmair Klaus, Blankenstein Thomas, Hansmann Leo
Abstract excerpt
Multiple myeloma is a hematologic malignancy of monoclonal plasma cells that accumulate in the bone marrow. Despite their clinical and pathophysiologic relevance, the roles of bone marrow-infiltrating T cells in treatment-naïve patients are incompletely understood. We investigated whether clonally expanded T cells (i) were detectable in multiple myeloma bone marrow, (ii) showed characteristic immune phenotypes,...
Topics
- Humans
- Multiple Myeloma
- Bone Marrow
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- Phenotype